Don Roos’s film adaptation of Love and Other Impossible Pursuits is set to premier at the Toronto International Film Festival.

The film, based on Ayelet Waldman’s novel and staring Natalie Portman, will be one of 335 films from 64 countries that will screen at the festival, which runs from Sept. 10 through 19. Seventy-one other films will also have their world premier at the festival.

Here’s how the film is described in TIFF’s press release, which was issued last week:

“Emilia Woolf (Natalie Portman) is a Harvard law school graduate and a newlywed, having just married Jack, her high-powered New York lawyer boss (Scott Cohen). Her life takes an unexpected turn when the couple loses their newborn daughter. Emilia struggles through her grief to connect with her precocious new stepson William (Charlie Tahan), overcome a rift in her relationship with her father caused by his infidelity, and cope with the constant interferences of Jack’s angry, jealous ex-wife (Lisa Kudrow). An adaptation of an Ayelet Waldman novel, this tearful and terrific tale by writer-director Don Roos proves that even with a pursuit like love, nothing is impossible.”